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Clinical Trials
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Finding out about a trial :
What are clinical trials and why do we need them?
Different types of clinical trial
Being asked about taking part in a trial
Information and questions
Difficulties finding a trial to join
Deciding whether to take part – risk and benefits :
Reasons for wanting to take part – personal benefit
Reasons for wanting to take part – helping medical science
Deciding not to take part
Thinking about withdrawing from a trial
Why people may not be eligible to join a trial
Being in a trial :
Feelings about being allocated (randomised) to a treatment group
Feelings about being in a placebo-controlled trial
Blinded trials
Non-randomised trial designs and other studies
Side effects and queries
Time commitment, money and other practical issues
Appointments, monitoring, questionnaires
Communication between different health professionals
At the end of a trial :
Feelings when a trial ends
Feedback of trial results
Other issues :
Attitudes to taking part in another trial
Funding and publishing trials
Public awareness and involvement
Under-researched topics/priorities for other research
Messages to other people
Messages to professionals
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Clinical Trials
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Medical research
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Clinical Trials
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Not taking part in a trial
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Charles - Interview 29
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He did not mind the idea of a placebo, and would have been curious to see if he was susceptible to the placebo effect. He might have dropped out if he
Charles volunteered for two trials, but ended up unable to take part in either of them. The first time he did not meet the eligibility criteria. The second time was because of an administrative mix-up about his age, and he feels it was not well handled.
Medical research
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Clinical Trials
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Screening, prevention other medical interventions
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Jenny - Interview 40
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Jenny can’t imagine any condition where she’d be willing to think about a placebo-controlled trial. She recognises the possibility of benefiting from
Jenny is in a trial of different ways of treating heavy periods at her GP surgery. The trial compares standard treatment with a new kind of coil or intrauterine device which releases a hormone in the womb.
Medical research
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Clinical Trials
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Long term conditions
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David - Interview 34
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He’d have been interested to see what happened if he had been in the placebo group. Before the trial he might have felt disappointed to get a placebo
David volunteered for a placebo-controlled trial of a new treatment derived from mouse DNA to improve asthma symptoms. He later discovered he was in the group taking a lower dose of the treatment, but he would not have minded being in the placebo group.
Medical research
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Clinical Trials
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Not taking part in a trial
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Polly - Interview 09
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She would probably have taken part if tamoxifen had been available only through a clinical trial. She is not against placebo-controlled trials in prin
Polly was invited to be in a trial comparing tamoxifen against a placebo for breast cancer in the 1990s. She decided not to take part, because she felt there was already good evidence to support the use of tamoxifen.
Medical research
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Clinical Trials
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Screening, prevention other medical interventions
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Jenny - Interview 40
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Filling in the questionnaire about her symptoms prompted Jenny to realise that the treatment wasn’t working, so she went back to her GP.
Jenny is in a trial of different ways of treating heavy periods at her GP surgery. The trial compares standard treatment with a new kind of coil or intrauterine device which releases a hormone in the womb.
Medical research
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Clinical Trials
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Long term conditions
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Angela - Interview 23
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Angela would take part in a trial another time, including a placebo-controlled trial, because she feels it’s important for medical science.
Angela was diagnosed with Parkinson’s disease after taking part in a trial on nerve conduction. She has since been in a randomised trial of different drugs for Parkinson’s and would happily take part in another trial, despite having had side effects.(Angela is also on our Parkinson’s disease site, Interview 10).
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