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Clinical Trials
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Full list of topics
Finding out about a trial :
What are clinical trials and why do we need them?
Different types of clinical trial
Being asked about taking part in a trial
Information and questions
Difficulties finding a trial to join
Deciding whether to take part – risk and benefits :
Reasons for wanting to take part – personal benefit
Reasons for wanting to take part – helping medical science
Deciding not to take part
Thinking about withdrawing from a trial
Why people may not be eligible to join a trial
Being in a trial :
Feelings about being allocated (randomised) to a treatment group
Feelings about being in a placebo-controlled trial
Blinded trials
Non-randomised trial designs and other studies
Side effects and queries
Time commitment, money and other practical issues
Appointments, monitoring, questionnaires
Communication between different health professionals
At the end of a trial :
Feelings when a trial ends
Feedback of trial results
Other issues :
Attitudes to taking part in another trial
Funding and publishing trials
Public awareness and involvement
Under-researched topics/priorities for other research
Messages to other people
Messages to professionals
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Clinical Trials
Subject index
Topic
Medical research
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Clinical Trials
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Why people may not be eligible to join a trial
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Why people may not be eligible to join a trial
Why people may not be eligible to join a trial
Medical research
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Clinical Trials
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Difficulties finding a trial to join
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Difficulties finding a trial to join
Difficulties finding a trial to join
Clip
Medical research
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Clinical Trials
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Not taking part in a trial
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Gill - Interview 10
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She assumed her local hospital would have plenty of research going on she could join, but when she asked there was nothing suitable for her.
Gill discovered she had breast cancer in 2007. She would have liked to take part in a trial to help other women with breast cancer in future, but none was available.
Medical research
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Clinical Trials
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Long term conditions
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Sarah - Interview 38
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Sarah wouldn’t take part in another trial involving anything invasive. She started a trial of lipids medication, but was disappointed to learn she was
Sarah volunteered for a placebo-controlled trial of a drug intended to help women at risk of osteoporosis. It involved daily injections and eventually she dropped out of the trial. (You can see Sarah talking more about her experiences on the healthtalkonline site osteoporosis, Interview 27).
Medical research
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Clinical Trials
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Screening, prevention other medical interventions
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Sabiha - Interview 19
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As a diabetic, she knew she was at risk from high cholesterol. She was glad to learn her cholesterol levels were too low to join the trial, but disapp
Sabiha took part in a trial of breast screening for younger women (under 50). More recently she volunteered for a trial of cholesterol-lowering drugs but was not eligible because her cholesterol level was too low.
Medical research
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Clinical Trials
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Cancer - Non-randomised studies
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Tom - Interview 14
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Tom believes a public website listing available trials and eligibility criteria would be a good idea. But he knows some doctors disagree, and thinks s
Tom took part in a phase 2 trial of a new chemotherapy drug for lung cancer in 1993. Without the trial, the only other option at the time would have been palliative radiotherapy.
Medical research
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Clinical Trials
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Not taking part in a trial
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Charles - Interview 29
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Charles volunteered for a trial involving prostate cancer testing. He was pleased to discover he was at low risk, as he thinks there is a family histo
Charles volunteered for two trials, but ended up unable to take part in either of them. The first time he did not meet the eligibility criteria. The second time was because of an administrative mix-up about his age, and he feels it was not well handled.
Medical research
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Clinical Trials
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Mental health trials
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Anton - Interview 28
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Researchers could do more to make it easy for people to volunteer. It’s off-putting when you ring to ask about a trial and you get an answerphone.
Anton has a long history of depression and has volunteered for several different trials in mental health, including trials of talking therapies as well as drug trials.
Medical research
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Clinical Trials
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Not taking part in a trial
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Charles - Interview 29
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He volunteered for another trial, testing a nasal inhaler for erectile dysfunction. He checked at the first appointment that he was in the eligible ag
Charles volunteered for two trials, but ended up unable to take part in either of them. The first time he did not meet the eligibility criteria. The second time was because of an administrative mix-up about his age, and he feels it was not well handled.
Medical research
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Clinical Trials
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Not taking part in a trial
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Charles - Interview 29
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After a lengthy second appointment, an administrator spotted that he had just turned 66, so he was told he was ineligible. He felt it was badly handle
Charles volunteered for two trials, but ended up unable to take part in either of them. The first time he did not meet the eligibility criteria. The second time was because of an administrative mix-up about his age, and he feels it was not well handled.
Medical research
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Clinical Trials
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Mental health trials
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Anton - Interview 28
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Anton does not take no for an answer and will go to great lengths to persuade staff to include him in a trial, even if he does not meet the eligibilit
Anton has a long history of depression and has volunteered for several different trials in mental health, including trials of talking therapies as well as drug trials.
Medical research
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Clinical Trials
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Not taking part in a trial
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Charles - Interview 29
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Now Charles is on a research unit database he hears about other relevant trials, but many people must get missed and GPs are probably selective in wha
Charles volunteered for two trials, but ended up unable to take part in either of them. The first time he did not meet the eligibility criteria. The second time was because of an administrative mix-up about his age, and he feels it was not well handled.
Medical research
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Clinical Trials
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Long term conditions
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Danny - Interview 26
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When it was discovered her summer holiday clashed with the next trial appointment, Danny was told she might be excluded. The word ‘excluded’ made her
Danny joined a trial of high blood pressure medication, but stopped because of side effects. She has concerns about the way some staff communicated with her and a lack of rapport and respect for her as a volunteer interested in her own health.
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