Please be very patient with us. We are stressed, we are very, very worried about our conditions, we are very scared, we are going into an unknown area and that can be very, very worrying. Please answer all our questions. Some of them may seem stupid to you, sometimes we may not take on board everything you say to us. Please do put up with us when we do ask you the same thing, we ask you to repeat things in a different way. Please let us bring somebody with us, and make sure that they’re included in any discussions, and just we rely on you for your help, so you’ve got to make sure that we can trust you, so therefore you’ve got to give us confidence in the trial, and explain all, explain it all in words of one syllable. You’ve got to explain the advantages, you’ve got to explain the disadvantages – okay, so at the end of the day you leave us to weigh it up for ourselves, but your guidance is absolutely vital and that’s what we need.