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• Bones & joints >> Rheumatoid Arthritis >> Anti-inflammatory drugs >> Anti-inflammatory drugs

Anti-inflammatory drugs (NSAIDs)

• Clip
• Bones & joints >> Rheumatoid Arthritis >> Interview 58 >> Professor Moots talks about the limitations of anti-TNF therapy.

Robert Moots, Professor of Rheumatology, School of Clinical Sciences at the University of Liverpool and Consultant Rheumatologist at University Hospital Aintree, Liverpool.

• Bones & joints >> Rheumatoid Arthritis >> Interview 58 >> Professor Robert Moots explains about biologic treatments for rheumatoid arthritis.

Robert Moots, Professor of Rheumatology, School of Clinical Sciences at the University of Liverpool and Consultant Rheumatologist at University Hospital Aintree, Liverpool.

• Bones & joints >> Rheumatoid Arthritis >> Disease duration 6-10 years >> Tara - Interview 53 >> Talks about why they changed her medication to an anti-TNF treatment and the changes it has made to her quality of life.

Following her diagnosis Tara was put on Methotrexate and this controlled her illness very well. She came off Methotrexate after deciding to have a second child. She describes her antenatal care as 'excellent' and felt safe and reassured. She is currently on anti-TNF treatment: Humira.

• Bones & joints >> Rheumatoid Arthritis >> Disease duration 0-5 years >> Kate - Interview 52 >> She was almost housebound because of her RA. Doctors started her on etanercept (Enbrel) and provided the necessary information but did not promise any

None of her previous non-biologic treatments have worked long-term. Her condition deteriorated to such an extent that she was housebound and needed help with most things. Currently she is on Enbrel and Methotrexate and her condition is much improved.

• Bones & joints >> Rheumatoid Arthritis >> Interview 58 >> Professor Robert Moots advices and informs about biologic drugs and pregnancy.

Robert Moots, Professor of Rheumatology, School of Clinical Sciences at the University of Liverpool and Consultant Rheumatologist at University Hospital Aintree, Liverpool.

• Bones & joints >> Rheumatoid Arthritis >> Disease duration 0-5 years >> Kate - Interview 52 >> She was almost housebound because of her RA. Doctors started her on etanercept (Enbrel) and provided the necessary information but did not promise any

None of her previous non-biologic treatments have worked long-term. Her condition deteriorated to such an extent that she was housebound and needed help with most things. Currently she is on Enbrel and Methotrexate and her condition is much improved.

• Bones & joints >> Rheumatoid Arthritis >> Disease duration 0-5 years >> Kate - Interview 52 >> Talks about her hospital appointments, including her anti-TNF clinic and the type of tests she has done. She says that there is a lot of monitoring be

None of her previous non-biologic treatments have worked long-term. Her condition deteriorated to such an extent that she was housebound and needed help with most things. Currently she is on Enbrel and Methotrexate and her condition is much improved.

• Bones & joints >> Rheumatoid Arthritis >> Disease duration 6-10 years >> Tara - Interview 53 >> She was 'amazed' to be given lots of information and advice about her anti-TNF medication. Says that she put her concerns about side effects of Humira

Following her diagnosis Tara was put on Methotrexate and this controlled her illness very well. She came off Methotrexate after deciding to have a second child. She describes her antenatal care as 'excellent' and felt safe and reassured. She is currently on anti-TNF treatment: Humira.

• Bones & joints >> Rheumatoid Arthritis >> Disease duration 0-5 years >> Kate - Interview 52 >> At every opportunity, her consultant raises the issue of the importance of not getting pregnant while on Enbrel. She and her husband have decided not

None of her previous non-biologic treatments have worked long-term. Her condition deteriorated to such an extent that she was housebound and needed help with most things. Currently she is on Enbrel and Methotrexate and her condition is much improved.

• Bones & joints >> Rheumatoid Arthritis >> Disease duration 0-5 years >> Kate - Interview 52 >> At every opportunity, her consultant raises the issue of the importance of not getting pregnant while on Enbrel. She and her husband have decided not

None of her previous non-biologic treatments have worked long-term. Her condition deteriorated to such an extent that she was housebound and needed help with most things. Currently she is on Enbrel and Methotrexate and her condition is much improved.

• Bones & joints >> Rheumatoid Arthritis >> Disease duration 11-15 years >> Sarah - Interview 54 >> She couldn't cope with the side effects of methotrexate and stopped taking it. One of her consultants accepted her decision but another warned her tha

Until two years ago Sarah had very bad arthritis and was in severe pain. Her consultant applied and was granted funding to put her on anti-TNF treatment: Enbrel. Sarah describes Enbrel as 'completely and totally changing her life'.

• Bones & joints >> Rheumatoid Arthritis >> Disease duration 0-5 years >> Kate - Interview 52 >> Says that the benefits of her treatment outweigh any concerns she might have about side effects because she didn't have “much of a life anyway”.

None of her previous non-biologic treatments have worked long-term. Her condition deteriorated to such an extent that she was housebound and needed help with most things. Currently she is on Enbrel and Methotrexate and her condition is much improved.

• Bones & joints >> Rheumatoid Arthritis >> Disease duration 11-15 years >> Sarah - Interview 54 >> Says that she has a more positive outlook on life since starting on Enbrel because she knows her RA is under control and talks about what she is able

Until two years ago Sarah had very bad arthritis and was in severe pain. Her consultant applied and was granted funding to put her on anti-TNF treatment: Enbrel. Sarah describes Enbrel as 'completely and totally changing her life'.

• Bones & joints >> Rheumatoid Arthritis >> Disease duration 11-15 years >> Michelle - Interview 51 >> She explains that her anti-TNF drug is working well and that at present she prefers drug therapy to surgery because she is moving to France. Ankle dam

Michelle is currently on anti-TNF treatment: Humira. She has taken Methotrexate for a number of years but has had breaks in between following a biopsy that revealed liver scarring. Michelle was diagnosed with osteopenia (a milder form of osteoporosis) in her spine and needs to take calcium tablets regularly.

• Bones & joints >> Rheumatoid Arthritis >> Disease duration 16-20 years >> Melissa - Interview 50 >> She has tried Enbrel and Humira but both drugs are not longer effective on her RA. At the time of the interview she was due to start on influximab.

Melissa was first diagnosed with juvenile idiopathic arthritis and later with rheumatoid arthritis. She was on Methotrexate for about eight years. She has been on two Anti-TNF treatments: etanercepts (Enbrel) and adalimumab (Humira) and expects to be started on influximab soon.

• Bones & joints >> Rheumatoid Arthritis >> Disease duration 0-5 years >> Georgina - Interview 57 >> She started on B-cell therapy rituximab in October 2007. Previously she has tried two anti-TNF drugs. She has noticed some improvement in her conditio

Diagnosed two years ago Georgina has been on B-cell therapy rituximab since November 2007. Previously she was on anti-TNF therapies; Humira and Enbrel. Her diagnosis of RA came about after her Pain Syndrome consultant referred her to the rheumatology clinic.

• Bones & joints >> Rheumatoid Arthritis >> Disease duration 11-15 years >> Michelle - Interview 51 >> She explains that her anti-TNF drug is working well and that at present she prefers drug therapy to surgery because she is moving to France. Ankle dam

Michelle is currently on anti-TNF treatment: Humira. She has taken Methotrexate for a number of years but has had breaks in between following a biopsy that revealed liver scarring. Michelle was diagnosed with osteopenia (a milder form of osteoporosis) in her spine and needs to take calcium tablets regularly.

• Bones & joints >> Rheumatoid Arthritis >> Disease duration 11-15 years >> Sarah - Interview 54 >> Says that she has a more positive outlook on life since starting on Enbrel because she knows her RA is under control and talks about what she is able

Until two years ago Sarah had very bad arthritis and was in severe pain. Her consultant applied and was granted funding to put her on anti-TNF treatment: Enbrel. Sarah describes Enbrel as 'completely and totally changing her life'.

• Bones & joints >> Rheumatoid Arthritis >> Disease duration 11-15 years >> Sarah - Interview 54 >> She couldn't cope with the side effects of methotrexate and stopped taking it. One of her consultants accepted her decision but another warned her tha

Until two years ago Sarah had very bad arthritis and was in severe pain. Her consultant applied and was granted funding to put her on anti-TNF treatment: Enbrel. Sarah describes Enbrel as 'completely and totally changing her life'.

• Bones & joints >> Rheumatoid Arthritis >> Disease duration 0-5 years >> Kate - Interview 52 >> At every opportunity, her consultant raises the issue of the importance of not getting pregnant while on Enbrel. She and her husband have decided not

None of her previous non-biologic treatments have worked long-term. Her condition deteriorated to such an extent that she was housebound and needed help with most things. Currently she is on Enbrel and Methotrexate and her condition is much improved.

• Bones & joints >> Rheumatoid Arthritis >> Disease duration 6-10 years >> Tara - Interview 53 >> She was 'amazed' to be given lots of information and advice about her anti-TNF medication. Says that she put her concerns about side effects of Humira

Following her diagnosis Tara was put on Methotrexate and this controlled her illness very well. She came off Methotrexate after deciding to have a second child. She describes her antenatal care as 'excellent' and felt safe and reassured. She is currently on anti-TNF treatment: Humira.

• Bones & joints >> Rheumatoid Arthritis >> Interview 58 >> Professor Robert Moots advices and informs about biologic drugs and pregnancy.

Robert Moots, Professor of Rheumatology, School of Clinical Sciences at the University of Liverpool and Consultant Rheumatologist at University Hospital Aintree, Liverpool.

• Bones & joints >> Rheumatoid Arthritis >> Disease duration 0-5 years >> Kate - Interview 52 >> Talks about her hospital appointments, including her anti-TNF clinic and the type of tests she has done. She says that there is a lot of monitoring be

None of her previous non-biologic treatments have worked long-term. Her condition deteriorated to such an extent that she was housebound and needed help with most things. Currently she is on Enbrel and Methotrexate and her condition is much improved.

• Bones & joints >> Rheumatoid Arthritis >> Disease duration 0-5 years >> Kate - Interview 52 >> She was almost housebound because of her RA. Doctors started her on etanercept (Enbrel) and provided the necessary information but did not promise any

None of her previous non-biologic treatments have worked long-term. Her condition deteriorated to such an extent that she was housebound and needed help with most things. Currently she is on Enbrel and Methotrexate and her condition is much improved.

• Bones & joints >> Rheumatoid Arthritis >> Disease duration 6-10 years >> Tara - Interview 53 >> Talks about why they changed her medication to an anti-TNF treatment and the changes it has made to her quality of life.

Following her diagnosis Tara was put on Methotrexate and this controlled her illness very well. She came off Methotrexate after deciding to have a second child. She describes her antenatal care as 'excellent' and felt safe and reassured. She is currently on anti-TNF treatment: Humira.

• Bones & joints >> Rheumatoid Arthritis >> Interview 58 >> Professor Robert Moots explains about biologic treatments for rheumatoid arthritis.

Robert Moots, Professor of Rheumatology, School of Clinical Sciences at the University of Liverpool and Consultant Rheumatologist at University Hospital Aintree, Liverpool.

• Bones & joints >> Rheumatoid Arthritis >> Interview 58 >> Professor Moots talks about the limitations of anti-TNF therapy.

Robert Moots, Professor of Rheumatology, School of Clinical Sciences at the University of Liverpool and Consultant Rheumatologist at University Hospital Aintree, Liverpool.

• Bones & joints >> Rheumatoid Arthritis >> Disease duration 21-25 years >> Interview 19 >> The new treatments becoming available make her optimistic for the future for people with early RA.

Diagnosed 1980. Early treatment NSAID, pain killer and steroids. 9 operations e.g. joint replacement, neck fusion. Various DMARDS. Currently on Anti-TNF Infliximab/7 weeks. Methotrexate weekly, Prednisolone, Rofecoxib, hydroxychloriquine daily.

• Bones & joints >> Rheumatoid Arthritis >> Disease modifying anti-rheumatic drugs (DMARDs) >> Disease modifying anti-rheumatic drugs (DMARDs)

Disease Modifying Anti-Rheumatic Drugs (DMARDs)

• Bones & joints >> Rheumatoid Arthritis >> Disease duration 11-15 years >> Interview 33 >> Having taken medication for twelve years she saw it as 'a way of life'.

Juvenile chronic arthritis diagnosed 1990. Initially NSAIDs, then methotrexate but nausea & then oral steroids from age 15. Finger tendon repair & hip replacement (01) Currently Anti-TNF Humira injected 2/month, indometacin, co-codamol & Lansoprazole.

• Bones & joints >> Rheumatoid Arthritis >> Disease duration 21-25 years >> Interview 19 >> Takes a 'cocktail' of drugs, would like to stop taking steroids but knows they help her mobility.

Diagnosed 1980. Early treatment NSAID, pain killer and steroids. 9 operations e.g. joint replacement, neck fusion. Various DMARDS. Currently on Anti-TNF Infliximab/7 weeks. Methotrexate weekly, Prednisolone, Rofecoxib, hydroxychloriquine daily.

• Bones & joints >> Rheumatoid Arthritis >> Interview 49 >> What is rheumatoid arthritis? - Introduced by Professor David Blake, Royal National Hospital for Rheumatic Diseases.

Gives a video introduction 'What is Rheumatoid arthritis?'

• Bones & joints >> Rheumatoid Arthritis >> Disease duration 21-25 years >> Interview 11 >> After about 8 years of taking steroids and penicillamine she decided to stop and slowly did so with her Doctor's advice.

RA diagnosed after months of knee and elbow pain and reduced mobility. Many joint injections. Took steroids & Penacillamine for 10 years but chose to stop. Now Co-odamol 4/day and blood pressure drugs. 2 Carpal tunnel operations & wrist bone removal.

• Bones & joints >> Rheumatoid Arthritis >> Disease duration 0-5 years >> Interview 24 >> She counts a week's supply of tablets into a medicine cup to help her remember whether or not she has taken her medication.

Diagnosed April 1997 after sudden onset of symptoms and admission to hospital. RA widespread leading to initial depression. Side-effects from Methotrexate so now taking Leflunomide 20mg/day, Rofecoxib 12.5mg/ alternate days and pain killers as required.

• Bones & joints >> Rheumatoid Arthritis >> Disease duration 16-20 years >> Interview 25 >> Uses a special tablet box to help her remember to take her drugs regularly.

Juvenile chronic arthritis diagnosed '85, on steroids since. Hip replacements age 23 & 32, 2 knees together at 36 & wrist/hand ops. Currently Methotrexate, Prednisolone, Rofecoxib & Tramadol. Cinnarizine & Stemetil for side effects - balance loss & nausea.

• Bones & joints >> Rheumatoid Arthritis >> Long term use of drugs >> Long term use of drugs

Long term use of drugs 

• Bones & joints >> Rheumatoid Arthritis >> Disease duration 21-25 years >> Interview 36 >> The RA got worse when she was a teenager. It affected her psychologically as well as physically and stopped her going to school.

Diagnosed 1979 as a young child. Currently on Methotrexate 10mg & folic acid, tramadol 100mg 2/day, solpadol 7/day. 2 hips and 2 knees replaced under spinal anaesthetic in succession over 2 years. Broken femur complication of last knee operation.