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• Bones & joints >> Rheumatoid Arthritis >> Disease duration 16-20 years >> Melissa - Interview 50 >> She has tried Enbrel and Humira but both drugs are not longer effective on her RA. At the time of the interview she was due to start on influximab.

Melissa was first diagnosed with juvenile idiopathic arthritis and later with rheumatoid arthritis. She was on Methotrexate for about eight years. She has been on two Anti-TNF treatments: etanercepts (Enbrel) and adalimumab (Humira) and expects to be started on influximab soon.

• Bones & joints >> Rheumatoid Arthritis >> Disease duration 0-5 years >> Kate - Interview 52 >> She was almost housebound because of her RA. Doctors started her on etanercept (Enbrel) and provided the necessary information but did not promise any

None of her previous non-biologic treatments have worked long-term. Her condition deteriorated to such an extent that she was housebound and needed help with most things. Currently she is on Enbrel and Methotrexate and her condition is much improved.

• Bones & joints >> Rheumatoid Arthritis >> Disease duration 11-15 years >> Sarah - Interview 54 >> She couldn't cope with the side effects of methotrexate and stopped taking it. One of her consultants accepted her decision but another warned her tha

Until two years ago Sarah had very bad arthritis and was in severe pain. Her consultant applied and was granted funding to put her on anti-TNF treatment: Enbrel. Sarah describes Enbrel as 'completely and totally changing her life'.

• Bones & joints >> Rheumatoid Arthritis >> Disease duration 11-15 years >> Sarah - Interview 54 >> Says that she has a more positive outlook on life since starting on Enbrel because she knows her RA is under control and talks about what she is able

Until two years ago Sarah had very bad arthritis and was in severe pain. Her consultant applied and was granted funding to put her on anti-TNF treatment: Enbrel. Sarah describes Enbrel as 'completely and totally changing her life'.

• Bones & joints >> Rheumatoid Arthritis >> Disease duration 6-10 years >> Interview 31 >> Her husband helps her by injecting the Enbrel twice a week.

Diagnosed '93 after quick onset. Side-effects from various DMARDs. Currently on Enbrel (anti TNFa) twice a week, Brufen retard 2400mg/day, Prednisolone 7.5mg/day and Paracetemol as required. Both elbows replaced (2002) and knee washout operation.

• Bones & joints >> Rheumatoid Arthritis >> Disease duration 6-10 years >> Interview 31 >> Felt the effects of Enbrel straight away and has less inflammation and more strength.

Diagnosed '93 after quick onset. Side-effects from various DMARDs. Currently on Enbrel (anti TNFa) twice a week, Brufen retard 2400mg/day, Prednisolone 7.5mg/day and Paracetemol as required. Both elbows replaced (2002) and knee washout operation.